Past studies have suggested that artificial sweeteners may actually work against our efforts to lose weight. Harvard researchers may have uncovered why.

In a series of laboratory experiments, the researchers found that aspartame (NutraSweet, Equal) actually blocked an enzyme called intestinal AP that plays an important role in maintaining normal metabolic function.

When this enzyme does not function properly, weight gain, metabolic syndrome and type 2 diabetes can follow. Additionally, the scientists found that lab mice fed a high-fat diet along with aspartame sweetened water gained significantly more weight, had higher blood sugar levels as well as blood inflammation markers than identical mice fed the same high fat diet along with plain water.

Just FYI – there is NOT any substantial long-term data to support the use of artificial sweeteners for weight control. Based on studies I have reviewed, as well as personal clinical experience –  I am convinced they work against us in the long term.

(Applied Physiology, Nutrition, and Metabolism, 2016; DOI: 10.1139/apnm-2016-0346)

 

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